Department of Medicine
University of Wisconsin
FRANK M GRAZIANO
Contact Information
600 HIGHLAND AVE
MADISON, WI 53792
Mail Code: 3244
Biography
Frank Graziano joined the faculty at the University of Wisconsin Hospital and Clinics in 1978. Dr. Graziano received his MD and PhD (Immunology) from the University of Virginia, Charlottesville. He did Internal Medicine training at the University of Wisconsin Hospital and Clinics, and Allergy/Immunology - Rheumatology fellowship training at Yale University Hospital, New Haven. Dr. Graziano is Board Certified in Internal Medicine, Allergy/Immunology, and Diagnostic Laboratory Immunology and is Board eligible in Rheumatology. He has been at the University of Wisconsin for 29 years and is past Chair of the Section of Rheumatology and currently is Director of the AIDS/HIV Clinic at the University Hospital.Dr. Graziano's research interests have been both basic and clinical. His basic research interests have dealt with an animal model of airway hyperresponsiveness and the role of the mast cell in this process. Over his career he has received a Young Investigator Award, Career Development Award, and RO1 support from the NIH. In 1993, his focus changed to the evaluation of mast cell involvement in human ocular disease. Since 1993, he has had continuous support for this project through NIH RO1 funding and special grants from the pharmaceutical industry. Dr. Graziano has served on NIH and VA study sections and is past Chair of the VA Immunology Study section.
Dr. Graziano's clinical research interests have focused on rheumatologic and HIV disease. He has performed numerous clinical studies examining treatment of rheumatoid arthritis and osteoarthritis. Most recently he has examined the role of TNF alpha in the treatment of rheumatoid arthritis. He also has received funding for the rheumatology Patient Partner program (a program in which patients teach the rheumatologic exam to medical students). Dr. Graziano is also the Director of HIV Care at the University of Wisconsin Hospital and Clinics. He has NIH funding to study the usefulness of Positron Emission Tomography (PET) in the diagnosis of HIV disease and pharmaceutical support to study IL-2 as therapy for HIV disease. Recently, the UWHC HIV Care program received Ryan White Care Act funding for HIV care at the University of Wisconsin.
Dr. Graziano has a broad base in education, administration and mentoring. He has been a Past Chair and Director of the Clinical Immunology Course taught at the University of Wisconsin School of Medicine and Public Health. He currently is faculty (and member of the coordinating committee) for the Infection and Immunity course taught to the second year medical students. Dr. Graziano has mentored numerous trainees in Rheumatology and Allergy/Immunology. Six individuals are currently in successful academic positions. His broad base in teaching, mentoring, research, and administration has lead to his appointment as Program Director for the NIH K30 grant awarded one year ago to the University of Wisconsin School of Medicine and Public Health. This award supports young physicians pursuing translational clinical research.
Dr. Graziano is Chair of the HIV Committee, University of Wisconsin Hospital and Clinics, and Past Chair of the HIV Committee American Academy of Allergy, Asthma, and Immunology (AAAAI). He has been a member of the Governor's (Wisconsin) Task Force on HIV Disease. He is also past Chair of the Sports Medicine Committee (AAAAI). In 1997, he was elected Governor of the Wisconsin Chapter of the American College of Physicians - American Society of Internal Medicine.
Search for Frank Graziano's literature abstracts on PubMed
Cook EB, Stahl JL, Sedgwick JB, Barney NP, and Graziano FM. The Promotion of Eosinophil Degranulation and Adhesion to Conjunctival Epithelial Cells by IgE-Activated Conjunctival Mast Cells. Ann Aller Asthma Immunol. 2004; 91:1-8.
Trepanier LA, Yoder AR, Bajad S, Beckwith MD, Bellehumeur JL, Graziano FM. Plasma Ascorbate Deficiency is Associated with Impaired Reduction of Sulfamethoxazole-Nitroso in HIV infection. J Acquir Immune Defic Syndr 2004; 36(5):1041-1050.
Cook E.B.; Stahl J.L.; Barney N.P.; Graziano F.M. Medicinal Chemistry Reviews - Online, July 2004, vol. 1, no. 3, pp. 333-347.
Cook EB, Stahl JL, Esnault S, Barney NP, Graziano FM. Toll-like receptor 2 expression on human conjunctival epithelial cells: A pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Ann Allergy Asthma Imm 2005; 94:486-497.
Lavergne SN, Kurian JR, Bajad SU, Maki JE, Yoder AR, Guzinski MV, Graziano FM, Trepanier LA. Roles of Endogenous Ascorbate and Glutathione in the Cellular Reduction and Cytotoxicity of Sulfamethoxazole-nitroso. Toxicology 2006; 222(1-2):25-36.
Cook EB, Stahl JL, Brooks AM, Graziano FM. Allergic Tears Promote Upregulation of Eosinophil Adhesion to Conjunctival Epithelial Cells in an Ex Vivo Model: Inhibition with Olopatadine Treatment. Investigative Ophthalmology and Visual Science, 2006; 47(8):3423-3429.