Department of Medicine
University of Wisconsin
MARC K DREZNER
Contact Information
750 HIGHLAND AVE
MADISON, WI 53705
Mail Code: 5148
Biography
Marc Drezner joined the faculty of the University of Wisconsin in March 2000, as Head of the Endocrinology, Diabetes and Metabolism Section. He is Professor of Medicine and also serves as the Director of the Clinical Osteoporosis Center.
Drezner graduated from the University of Pittsburgh with a BS in Chemistry and from the University of Pittsburgh Medical School. He received his internal medicine and endocrinology training at Duke University Medical Center and remained on the faculty of the Duke University Medical School for twenty-five years. During his tenure at Duke University he was appointed Associate Professor of Medicine in 1981 and Professor of Medicine in 1987. He served as Director of the Endocrinology and Diabetes Training Grant from 1983-2000 and Director of the Stedman Nutrition Center from 1991-1997.
Drezner is internationally known for his scientific work in bone and mineral metabolism and has made seminal contributions to our knowledge of several genetic diseases, including X-Linked Hypophosphatemic Rickets/Osteomalacia and Pseudohypoparathyroidism. In addition, he has brought new perspective to the management of Postmenopausal Osteoporosis, bringing attention to the psychosocial consequences of the disease. He is an experienced clinical and basic science investigator with more than 150 peer-reviewed original publications, more than 50 chapters and editorials, 2 books and numerous visiting professorships in the US and abroad.
His pioneering work in the bone and mineral field has led to discovering an new disease, Pseudohypopharathyroidism, Type 2, cloning the gene underlying the most common form of familial rickets, and defining and providing the name for a newly conceived hormone, phosphatonin. In the hypophosphatemic diseases of man, Drezner has helped set the reseach and clinical agendas worldwide and has contributed to defining the new therapeutic approaches for these diseases.
Drezner is on the Editorial Board of several journals and serves as the Editor Emeritus of the Journal of Bone and Mineral Research, the foremost clinical and basic science bone journal in the world today. He maintains an active clinical practice with specific interests in management of osteoporosis, hyperparathyroidism and rickets/osteomalacia.
Search for Marc Drezner's literature abstracts on PubMed
Nesbitt, T., Econs, M.J., Byun, J.K., Martel, J., Tenenhouse, H.S. and Drezner, M.K.: Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and hyp mice: Evidence that the Hyp gene locus product is an extrarenal factor. J Bone Min Res 10:1327-1333, 1995.
Nesbitt, T. and Drezner, M.K.: Normal phosphate transport in cell cultures from the proximal convoluted tubule of Gy-mice: evidence for a single defect underlying X-linked hypophosphatemia. Am J Physiol, 273:F113-F119, 1997.
Xiao, Z.S., Guo, R., Nesbitt, T., Drezner, M.K., Quarles, L.D.: Intrinsic mineralization defect in Hyp-mouse osteoblasts. Am J Physiol 275:E700-708, 1998.
Nesbitt, T., Thomas R, Quarles, L.D., and Drezner, M.K.: Coordinated maturational regulation of PHEX and renal phosphate transport inhibitory activity: evidence for the pathophysiological role of PHEX in XLH. J Bone Miner Res 14:2027-2035, 1999.
Drezner, M.K.: PHEX gene and hypophosphatemia. Kid Int 57:9-18, 2000.
Gold, D.T., Lyles, K.W., Harper, K.D., Shipp, K.M. and Drezner, M.K.: Unexpected consequences of osteoporosis: an evolving basis for treatment decisions. In: Osteoporosis, 2nd Edition. R. Marcus, D. Feldman, J. Kelsey (editors), Academic Press, San Diego, CA, In press.