Charles A. Mistretta, PhD J.R. Cameron Professor of Medical Physics and Radiology E3/311 CSC 600 Highland Avenue Madison, Wisconsin 53792 Phone: (608) 263-8313 Fax: (608) 263-0876 Email: camistre@facstaff.wisc.edu

Charles Mistretta received his doctorate in high energy physics at Harvard University in Boston in 1968. In 1983 he received the Laufman-Greatbatch Prize from the Association for the Advancement of Medical Instrumentation for developing digital subtraction angiography and in 1998, the J. Allyn Taylor International Prize in Medicine for 'distinguished lifetime achievement' and 'outstanding contributions to the advances in the use of medical imaging in diagnosing and treating human diseases.' He has served on numerous study sections for the National Institutes of Health (NIH), the Whitaker Foundation and various Canadian funding agencies. He has more than 120 invited presentations and visiting professorships to his credit.

Mistretta has graduated 23 medical imaging doctoral students. They have gone on to develop numerous clinically important imaging modalities such as spiral computed tomography (Kalender), magnetic resonance fluoroscopy (Riederer), thermoacoustic computed tomography (Kruger) and dual modality computed tomography/single photon emission computer tomography (Hasegawa).

Mistretta and his group developed digital subtraction angiography in the late 1970s. He has obtained 18 US patents and multiple foreign patents associated with the technology. Commercial sales of the real time digital angiography apparatus by licensees were in excess of one billion dollars during the life of principle patents. His recent work has focused on duplicating the capabilities of this technique with less invasive magnetic resonance methods, with a primary goal of imaging and characterizing coronary artery lesions.

Mistretta's current grants include:

• 2001-2005 National Institutes of Health 3D Contrast-Enhanced MR Angiography with High Resolution extended Acquisition
• 2002-2007 National Institutes of Phase Contrast Imaging Using Vastly Undersampled Isotropic Projection Imaging (VIPR)
• 2003-2005 National Institutes of Health Ultrafast Z-Scan X-ray Volume CT

Selected Publications

Y Mazaheri, TJ Carroll, J Du, FR Korosec, WF Block, SB Fain, KK Vigen, TM Grist, TF Hany, BD Aagaard, CM Strother, CA Mistretta. Combined Time-Resolved and High Spatial Resolution 3D MRA using an Extended Adaptive Acquisition, JMRI 15: 291-301, 2002.

TF Hany, TJ Carroll, RA Omary, E Esparza-Coss, FR Korosec, CA Mistretta, and TM Grist. Aorta and Runoff Vessels: Single-Injection MR Angiography with Automated Table Movement Compared with Multiinjection Time-resolved MR Angiography-Initial Results Radiology 221: 266-272, 2001.

AV Barger, TF Hany, CA Mistretta and TM Grist. Time-resolved Targeted Three-Dimensional Coronary Magnetic Resonance Imaging in a single Breath-hold using and Intravascular Contrast Agent, in preparation.

AV Barger, WF Block, Y Toropov, TM Grist, CA Mistretta. Time-Resolved Contrast-Enhanced Imaging with Isotropic Resolution and Broad Coverage Using an Undersampled 3D Projection Trajectory, Magn Reson Med. 48: 297-305, 2002.

J Du, TJ Carroll, HJ Wagner, K Vigen, SB Fain, WF Block, FR Korosec, TM Grist and CA Mistretta, Time-Resolved, Undersampled Projection Reconstruction Imaging for High Resolution CE-MRA of the Distal Runoff Vessels. Magn Reson Med. 48: 516-522, 2002.